1. 1 year ago 

    Oxígeno suplementario en pacientes con SCA

    We recommend supplemental oxygen for patients with an arterial saturation less than 90 percent, patients in respiratory distress, or those with other high risk features for hypoxemia.

    The role of supplemental oxygen in patients without hypoxia has not been well-studied. A 2010 Cochrane review evaluated three trials of 387 patients with presumed myocardial infarction (MI) who were randomly assigned to supplemental oxygen or room air. Enrolled patients were either hypoxic and normoxic. The study found no significant difference in mortality (pooled relative risk 2.88, [95% CI 0.88-9.39] in an intention-to-treat analysis and 3.03, [95% CI 0.93-9.83] among those with confirmed MI). No subgroup analysis was performed on those with normoxia.

    The suggestion of harm with supplemental oxygen found in this Cochrane review is of concern, particularly in patients with normoxia, as a pathophysiologic basis for such harm has been articulated. Hyperoxia, which might occur with the administration of oxygen to normoxic individuals, has been shown to have a direct vasoconstrictor effect on the coronary arteries.

    Reference: Cabello JB, Burls A, Emparanza JI, et al. Oxygen therapy for acute myocardial infarction. Cochrane Database Syst Rev 2010; :CD007160.

    (Source: uptodate.com)

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